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bioscaffolder_3d_printing

Bioscaffolder - Bio printing

The BioScaffolder 3.1 is a modular 3D printer platform with up to four independent z-axes for tool operation designed for 3D bio-printing.

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SKU: BioScaffolder 3.1
BioScaffolder 3.1
Customizable platform for Bioprinting

The BioScaffolder 3.1 get's your cells in shape!

The instrument prints a lot of biocompatible materials. Learn how to evolve your petri dish cell culture into an artificial piece of bone or skin.

At a Glance

The BioScaffolder 3.1 is a modular instrument platform with up to four independent z-axes for tool operation.

Standard:

  • Pneumatic Extruders (Optionally heated) for dispensing high-viscous/ pasty materials

Options:

  • Pipetting unit (Low-viscous liquid handling with pipet tips or piezoelectric Nanoliter dispenser)
  • Piezoelectric dispense valves for high-viscous materials (Third party)
  • Melt Electrospinning (MES, In development)
  • Syringe Extruders (In development)
  • Cameras
  • Exposition Lamps for Curing and UV-Hardening
  • Trays for target objects, e.g. cell culture plates
  • Software for Import of STL data

The Scaffold Generator of the BS3.1 software creates print maps for the BS3.1 without external CAD programs.

Basic geometric figures can be selected and parametrized. Stacking up of these basic figures allows more complex structures.

The interface between the Scaffold Generator and the instrument is based on Gcode.

The BS3.1 instrument adapts to your application as well as to your budget!

 
Pneumatic Extrusion
Computers, Cartridges and Pressurized Air: The heart of each BS3.1

BS3.1 comprises an external “F-Box” (Right picture) managing the media supply and removal for the instrument. Furthermore it contains the control computer of the instrument.

The basic pneumatic extruder allows individual pressure settings. BS3.1 supports 10 ml and 30ml cartridges (Left picture).

Pressure ranges from 0 to 7 bar.

  

 
Tools & Calibration
Many Tools, Different Materials: Click and Go!

Biomaterials of very different consistencies require very different tools (sizes) but need to be printed into one structure.

On top of this, any 3D printer works only when the first layer is well aligned to the building platform.

The BS3.1 comes with optical and mechanical calibration tools for the automatic offset compensation between the tools and the ground level.

The only things you have to do is load your material, find the right pressure for extrusion and create your model.

Then you are just a few mouse clicks away from your ready printed scaffold.

 

 BS3.1 combines different tools for building 3D structures with several materials

 

Options

cartridge heater
3D Structures from Melted Thermoplastics

The standard cartridge heater for BS3.1 adapts 10mL disposable cartridges like from Nordson GLT. It is temperature controlled and goes up to 120°C.

It keeps cell suspensions at 37°C or gives precise prints of PCL (PolyCaproLactone) thermoplastics with melting point around 70°C.

Later on a power heater will become available for proprietary metal cartridges. It extends the temperature range up to 250°C.

           

Cartridge slot with heater for 10ml cartridges (BS2.1)              Micron-S nozzle (Nickel silver or phosphor bronze, optional coatings) with Luer-lock for the BS3.1 heater=

The cartridge heater shall be used with metal nozzles (right picture) for better heat transfer to the orifice.

 

Trays
Tablets for Object Fixation

The standard tray for BS3.1 accomodates two well plates, e.g.

cell culture plates. Trays for glass slides or other targets are available on request.

The trays come with a snap-in fixation for quick replacement on the instrument main deck.

Well plate tray

 

Pipetting Unit
Low-Volume Sample Handling

Optionally BS3.1 can be equipped with a pipetting unit. A pipetting needle applies small volumes of low-viscous liquids to previously printed scaffold struts.

These liquids may contain drugs, cells or particular proteins.

There are two tools available:

  • Passive needle for syringe supported displacement dispensing. The lowest dispense volume might be half a Microliter.
  • Piezoelectric nozzles for free-flight microdrop dispensing. The lowest dispense volume is in the range of 0.1 Nanolitres:

Piezoelectric GeSiM dispensers emit single drops in the range of 250 Pikolitre (Drop diameter about 50 Microns).

Small amounts of proteins or cell suspensions can be applied to single or multiple layers of a bioscaffold structure during the printing process.

                     

Piezo Dispenser on a bioscaffold structure                 Heater for 96well plates (BS2.1)

Contradictionary to the cartridge system the pipetting unit aspirates from 96 well plates. Only a few Microliters of each species are required.

Heaters are available both for the sample plate and the piezo nozzle for producing microdrops of melted materials.

 

Curing and Photopolymerization
Hardening of Scaffold Struts

There are lamp heads with different excitation wave lengths and different wave length available for the exposition of printed scaffold layers (Third party manufacturers).

The lense head goes on one of the tool axes of BS3.1. One application is the hardening of UV curable materials.

THORLABS 4-fold LED head on BS3.1

For high power exposition we recommend the Omnicure 1500.

Alternatively, LED-lamps from THORLABS are available with many different wave lengths but at limited power.

The max. LED output power depends on the wavelength and is in the range of 50 mW to 210 mW.

 

3D CAD Models
Processing of External CAD Data

This extension just comprises software  – A dedicated input filter reads in STL files.

An STL file describes triangulated surfaces in a three-dimensional Cartesian coordinate system.

It is widely used for rapid prototyping, 3D printing and computer aided manufacturing.

3D models printed from STL files: Women breast model (left), bulbasaur (right)

The BioScaffolder 3.1 software allows to define inner “scaffold-” structures whereas the STL file brings in just surfaces.

Like with the built-in scaffold generator, up to three different materials and different pore sizes can be assigned to the CAD model.

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Gesim 2017 3D BioPrinter Catalog

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